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科学研究

代表性论文

1.    Wu, H. J., X. Y. Qu, Z. C. Dong, L. J. Luo, C. Shao, J. Forner, J. U. Lohmann, M. Su, M. C. Xu, X. B. Liu, L. Zhu, J. Zeng, S. M. Liu, Z. X. Tian and Z. Zhao (2020). WUSCHEL triggers innate antiviral immunity in plant stem cells. Science370(6513): 227-231.

2.    Ma, Y. Q., J. Bao, Y. W. Zhang, Z. J. Li, X. Y. Zhou, C. L. Wan, L. Huang, Y. Zhao, G. Han and T. Xue (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell177(2):243-255 e215.

3.    Zhu, H., Q. Li, T. Liao, X. Yin, Q. Chen, Z. Wang, M. Dai, L. Yi, S. Ge, C. Miao, W. Zeng, L. Qu, Z. Ju, G. Huang, C. Cang and W. Xiong (2021). Metabolomic profiling of single enlarged lysosomes. Nature Methods.

4.    Liu, Y. T., C. L. Tao, X. K. Zhang, W. J. Xia, D. Q. Shi, L. Qi, C. Xu, R. Sun, X. W. Li, P. M. Lau, Z. H. Zhou and G. Q. Bi (2020). Mesophasic organization of GABA(A)  receptors in hippocampal inhibitory synapses. Nature Neuroscience23(12): 1589-U1118.

5.    Zhu, X., H. D. Tang, W. Y. Dong, F. Kang, A. Liu, Y. Mao, W. Xie, X. L. Zhang, P. Cao, W. J. Zhou, H. T. Wang, Z. Farzinpour, W. J. Tao, X. Y. Song, Y. Zhang, T. Xue, Y. Jin, J. Li and Z. Zhang (2021). Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nature Neuroscience24(4): 542-553.

6.    Huang, Y., L. Lin, X. Liu, S. Ye, P. Y. Yao, W. Wang, F. Yang, X. Gao, J. Li, Y. Zhang, J. Zhang, Z. Yang, X. Liu, Z. Yang, J. Zang, M. Teng, Z. Wang, K. Ruan, X. Ding, L. Li, D. W. Cleveland, R. Zhang and X. Yao (2019). BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Research29(7): 562-578.

7.    Li, S. Y., F. Yang, D. M. Sun, Y. Zhang, M. G. Zhang, S. L. Liu, P. Zhou, C. W. Shi, L. H. Zhang and C. L. Tian (2020). Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis. Cell Research30(11): 1049-1052.

8.    Wang, J., Y. X. Gao, L. Chen, Y. G. Guo, S. Y. Hu, L. S. Cheng, W. H. Xiao, J. Y. Ke, Z. L. Zhu and L. W. Niu (2021). Structure of the platelet glycoprotein Ib receptor in complex with a novel antithrombotic agent. Blood137(6): 844-847.

9.    Chen, P., S. Lou, Z. H. Huang, Z. Wang, Q. H. Shan, Y. Wang, Y. Yang, X. Li, H. Gong, Y. Jin, Z. Zhang, and J. N. Zhou(2020). Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations. Neuron 106: 301-15 e7.

10.    Chen, X., S. Liao, Y. Makaros, Q. Guo, Z. Zhu, R. Krizelman, K. Dahan, X. Tu, X. Yao, I. Koren and C. Xu (2021). Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase. Nat Chem Biol17(3): 254-262.

11.    Xia, L. Y., Y. L. Jiang, W. W. Kong, H. Sun, W. F. Li, Y. X. Chen and C. Z. Zhou (2020). Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. Nature Plants6(6): 708-717.

12.    Liu, Y., H. Jiang, and Z. Hou(2021). Hidden Mechanism Behind the Roughness-Enhanced Selectivity of Carbon Monoxide Electrocatalytic Reduction. Angew Chem Int Ed Engl 60: 11133-37.

13.    Chen, J., Z. Wang, X. Guo, F. Li, Q. Wei, X. Chen, D. Gong, Y. Xu, W. Chen, Y. Liu, J. Kang and Y. Shi (2019). TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells. Nature Communications10(1): 4273.

14.    Bi, D., L. Wen, Z. Wu and Y. Shen (2020). GABAergic dysfunction in excitatory and inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer's disease. Alzheimers Dement16(9): 1312-1329.

15.    Long, P. P., L. Zhang, B. Huang, Q. Chen and H. Y. Liu (2020). Integrating genome sequence and structural data for statistical learning to predict transcription factor binding sites. Nucleic Acids Research48(22): 12604-12617.

16.    Lin, J. H., L. H. Yu and C. B. Xiang (2020). ARABIDOPSIS NITRATE REGULATED 1 acts as a negative modulator of seed germination by activating ABI3 expression. New Phytologist225(2): 835-847.

17.    Liu, Y. T., J. Jih, X. H. Dai, G. Q. Bi and Z. H. Zhou (2019). Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Nature570(7760): 257-261.

18.    An, K., H. Zhao, Y. Miao, Q. Xu, Y. F. Li, Y. Q. Ma, Y. M. Shi, J. W. Shen, J. J. Meng, Y. G. Yao, Z. Zhang, J. T. Chen, J. Bao, M. Zhang and T. Xue (2020). A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice. Nature Neuroscience23(7): 869-880.

19.    Zhou, W. J., Y. Jin, Q. Meng, X. Zhu, T. J. Bai, Y. H. Tian, Y. Mao, L. K. Wang, W. Xie, H. Zhong, N. Zhang, M. H. Luo, W. J. Tao, H. T. Wang, J. Li, J. Li, B. S. Qiu, J. N. Zhou, X. Y. Li, H. Xu, K. Wang, X. C. Zhang, Y. Liu, G. Richter-Levin, L. Xu and Z. Zhang (2019). A neural circuit for comorbid depressive symptoms in chronic pain. Nature Neuroscience22(10): 1649-1658.

20.    Liao, S. H., G. Rajendraprasad, N. Wang, S. Eibes, J. Gao, H. J. Yu, G. Wu, X. M. Tu, H. D. Huang, M. Barisic and C. Xu (2019). Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Research29(7): 533-547.

21.    Ling, S. L., P. Shi, S. L. Liu, X. Y. Meng, Y. X. Zhou, W. J. Sun, S. H. Chang, X. Zhang, L. H. Zhang, C. W. Shi, D. M. Sun, L. Liu and C. L. Tian (2021). Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan. Cell Research31(4): 383-394.

22.    Wang, L., W. T. Hou, L. Chen, Y. L. Jiang, D. Xu, L. F. Sun, C. Z. Zhou and Y. X. Chen (2020). Cryo-EM structure of human bile salts exporter ABCB11. Cell Research30(7): 623-625.

23.    Xu, D., Z. Feng, W. T. Hou, Y. L. Jiang, L. Wang, L. Sun, C. Z. Zhou, and Y. Chen. 2019. 'Cryo-EM structure of human lysosomal cobalamin exporter ABCD4', Cell Research, 29: 1039-41.

24.    Xin, J., Z. Xu, X. Wang, Y. Tian, Z. Zhang and G. Cai (2019). Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Research29(8): 655-665.

25.    Yang, Y., Z. Y. Xu, C. He, B. B. Zhang, Y. Y. Shi and F. D. Li (2019). Structural insights into the recognition of gamma-globin gene promoter by BCL11A. Cell Research29(11): 960-963.

26.    Yu, H. J., F. R. Yang, P. Dong, S. H. Liao, W. R. Liu, G. Y. Zhao, B. Qin, Z. Dou, Z. Liu, W. Liu, J. Y. Zang, J. Lippincott-Schwartz, X. Liu and X. B. Yao (2019). NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation. Cell Research29(8): 666-679.

27.    Yao, X. B., and A. J. Smolka. 2019. 'Gastric Parietal Cell Physiology and Helicobacter pylori-Induced Disease', Gastroenterology, 156: 2158-73.

28.    Li, C. Z., Y. L. Jiao, Y. Y. Zhang, S. J. Jiang, X. D. Lv, S. Z. Wu, J. W. Li, Y. L. Hu, J. X. Ye, K. Liu, D. Wu and J. R. Chu (2021). Noncontact All-In-Situ Reversible Reconfiguration of Femtosecond Laser-Induced Shape Memory Magnetic Microcones for Multifunctional Liquid Droplet Manipulation and Information Encryption. Advanced Functional Materials31(20).

29.    Jiang, H. J. and Z. H. Hou (2021). Mechanisms beyond energetics revealed by multiscale kinetic modeling of 2D-material growth and nanocatalysis. Wiley Interdisciplinary Reviews-Computational Molecular Science.

30.    Chen, C., Z. C. Huang, S. W. Zhu, B. R. Liu, J. W. Li, Y. L. Hu, D. Wu and J. R. Chu (2021). In Situ Electric-Induced Switchable Transparency and Wettability on Laser-Ablated Bioinspired Paraffin-Impregnated Slippery Surfaces. Advanced Science.e2100701.  doi: 10.1002/advs.202100701.

31.    Li, X. H., J. Zhang, D. F. Li, C. He, K. Q. He, T. Xue, L. L. Wan, C. Zhang and Q. Liu (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron109(6).

32.    Zhang, M., F. D. Li, K. Li, Z. L. Wang, Y. X. Wang, J. B. He, H. F. Su, Z. Y. Zhang, C. B. Chi, X. M. Shi, C. H. Yun, Z. Y. Zhang, Z. M. Liu, L. R. Zhang, D. H. Yang, M. Ma, X. Qiao, and M. Ye (2020). Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase from Glycyrrhiza glabra. Journal of the American Chemical Society, 142: 3506-12.

33.    Song, Q., X. N. Yan, H. Cui and M. M. Ma (2020). Efficient Cascade Resonance Energy Transfer in Dynamic Nanoassembly for Intensive and Long-Lasting Multicolor Chemiluminescence. Acs Nano14(3): 3696-3702.

34.    Ni, J. C., S. L. Liu, G. W. Hu, Y. L. Hu, Z. X. Lao, J. W. Li, Q. Zhang, D. Wu, S. H. Dong, J. R. Chu, and C. W. Qiu. 2021. 'Giant Helical Dichroism of Single Chiral Nanostructures with Photonic Orbital Angular Momentum', Acs Nano, 15: 2893-900.

35.    Gao, Q., L. Yang, A. Shen, Y. Li, Y. Li, S. Hu, R. Yang, X. Wang, X. Yao, and G. Shen. 2021. 'A WNT7B-m(6)A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis', Signal Transduct Target Ther, 6: 43.

36.    Chen, X. M., H. J. Yao, H. Wang, Y. Y. Mao, D. Liu and D. Long (2019). Extending the Lifetime of Native GTP-Bound Ras for Site-Resolved NMR Measurements: Quantifying the Allosteric Dynamics. Angewandte Chemie-International Edition58(9): 2730-2733.

37.    Huang, D. L., C. Montigny, Y. Zheng, V. Beswick, Y. Li, X. X. Cao, T. Barbot, C. Jaxel, J. Liang, M. Xue, C. L. Tian, N. Jamin, and J. S. Zheng. 2020. 'Chemical Synthesis of Native S-Palmitoylated Membrane Proteins through Removable-Backbone-Modification-Assisted Ser/Thr Ligation', Angewandte Chemie-International Edition, 59: 5178-84.

38.    Cheng, A. X., P. Zhang, B. Wang, D. D. Yang, X. T. Duan, Y. L. Jiang, T. Xu, Y. Jiang, J. H. Shi, C. T. Ding, G. Wu, Z. H. Sang, Q. Wu, H. Wang, M. Wu, Z. Y. Zhang, X. Pan, Y. Y. Pan, P. Gao, H. F. Zhang, C. Z. Zhou, J. Guo and Z. Y. Yang (2019). Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect. Nature Communications10.10(1):5566. doi: 10.1038/s41467-019-13485-8.  

39.    Huang, X., W. Sun, Z. Cheng, M. Chen, X. Li, J. Wang, G. Sheng, W. Gong and Y. Wang (2020). Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nature Communications11(1): 5241.

40.    Rasul, F., F. Zheng, F. F. Dong, J. J. He, L. Liu, W. Y. Liu, J. Y. Cheema, W. F. Wei and C. H. Fu (2021). Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex. Nature Communications12(1).

41.    Ye, J., G. Zou, R. Zhu, C. Kong, C. Miao, M. Zhang, J. Li, W. Xiong and C. Wang (2021). Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nature Communications12(1): 297.

42.    Zhang, Q., Y. H. Guo, W. T. Ji, M. Q. Wang, J. Yin, F. Kong, Y. H. Lin, C. M. Yin, F. Z. Shi, Y. Wang and J. F. Du (2021). High-fidelity single-shot readout of single electron spin in diamond with spin-to-charge conversion. Nature Communications12(1).

43.    Fang, T., W. Chen, Y. Sheng, S. Yuan, Q. Tang, G. Li, G. Huang, J. Su, X. Zhang, J. Zang, and Y. Liu. 2019. 'Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein', Nature Communications, 10: 186.

44.    Xie, G., T. V. Vo, G. Thillainadesan, S. Holla, B. Zhang, Y. Jiang, M. Lv, Z. Xu, C. Wang, V. Balachandran, Y. Shi, F. Li, and S. I. S. Grewal. 2019. 'A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing', Nature Communications, 10: 251.

45.    Tian, Y. K., H. Zheng, F. Zhang, S. L. Wang, X. R. Ji, C. Xu, Y. H. He and Y. Ding (2019). PRC2 recruitment and H3K27me3 deposition at FLC require FCA binding of COOLAIR. Science Advances5(4).

46.    Wang, P. F., S. Y. Chen, M. S. Guo, S. J. Peng, M. Q. Wang, M. Chen, W. C. Ma, R. Zhang, J. H. Su, X. Rong, F. Z. Shi, T. Xu and J. F. Du (2019). Nanoscale magnetic imaging of ferritins in a single cell. Science Advances5(4).

47.    Kong, F., P. J. Zhao, P. Yu, Z. Y. Qin, Z. H. Huang, Z. C. Wang, M. Q. Wang, F. Z. Shi and J. F. Du (2020). Kilohertz electron paramagnetic resonance spectroscopy of single nitrogen centers at zero magnetic field. Science Advances6(22).:eaaz8244

48.    Cheng, L., F. D. Li, Y. Y. Jiang, H. L. Yu, C. L. Xie, Y. Y. Shi and Q. G. Gong (2019). Structural insights into a unique preference for 3 terminal guanine of mirtron in Drosophila TUTase tailor. Nucleic Acids Research47(1): 495-508.

49.    Liu, X. D., S. Q. Shen, P. Z. Wu, F. D. Li, X. Liu, C. Y. Wang, Q. G. Gong, J. H. Wu, X. B. Yao, H. F. Zhang and Y. Y. Shi (2019). Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Research47(14): 7648-7665.

50.    Wang, F., D. L. Ren, X. L. Liang, S. W. Ke, B. W. Zhang, B. Hu, X. Y. Song and X. T. Wang (2019). A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research47(12): 6315-6329.

51.    Xue, L., J. Yue, J. Y. Ke, M. H. Khan, W. Wen, B. L. Sun, Z. L. Zhu and L. W. Niu (2020). Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system. Nucleic Acids Research48(18): 10527-10541.

52.    Luo, Z. Y., T. F. Hu, H. Jiang, R. Y. Wang, Q. L. Xu, S. M. Zhang, J. Cao and X. Y. Song (2020). Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila. Genome Research30(3): 406-414.

53.    Fang, J. W., Q. Ma, C. Chu, B. B. Huang, L. J. Li, P. F. Cai, P. Batista, K. E. M. Tolentino, J. Xu, R. Li, P. C. Du, K. Qu and H. Y. Chang (2019). PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications. Genome Biology 20(1):292. doi: 10.1186/s13059-019-1880-3. 

54.    Yin, T. T., Z. B. Zhao, J. Guo, T. C. Wang, J. B. Yang, C. Wang, J. Long, S. S. Ma, Q. Huang, K. G. Zhang, X. P. Ma, C. H. Liu, S. Liu, Z. X. Lian, and Z. Y. Yang. 2019. 'Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer', Cancer Research, 79: 3431-44.

55.    Weng, C., J. Kosalka, A. C. Berkyurek, P. Stempor, X. Feng, H. Mao, C. Zeng, W. J. Li, Y. H. Yan, M. Q. Dong, N. R. Morero, C. Zuliani, O. Barabas, J. Ahringer, S. Guang, and E. A. Miska. 2019. 'The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans', Genes Dev, 33: 90-102.

56.    Liu, D., Y. Y. Mao, X. Gu, Y. Zhou and D. Long (2021). Unveiling the invisible druggable conformations of GDP-bound inactive Ras. Proceedings of the National Academy of Sciences of the United States of America118(11).

57.    Wang, M. X., Q. Guo, K. F. Zhu, B. Fang, Y. F. Yang, M. K. Teng, X. Li and Y. Y. Tao (2020). Interface switch mediates signal transmission in a two-component system. Proceedings of the National Academy of Sciences of the United States of America117(48): 30433-30440.

58.    Ye, J., J. C. Li, F. Ye, Y. Zhang, M. J. Zhang and C. Wang (2020). Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance. Proceedings of the National Academy of Sciences of the United States of America117(2): 1207-1215.

59.    Sun, T., Z. Song, Y. Tian, W. Tian, C. Zhu, G. Ji, Y. Luo, S. Chen, L. Wang, Y. Mao, W. Xie, H. Zhong, F. Zhao, M. H. Luo, W. Tao, H. Wang, J. Li, J. Li, J. Zhou, K. Wang, and Z. Zhang(2019).  Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior. Proceedings of the National Academy of Sciences of the United States of America116: 3799-804.